Year: 2026
Type: article
Study design: Case Report
Abstract: Epithelioid sarcoma (ES) is a rare, aggressive soft tissue malignancy with substantial morphologic overlap with other epithelioid neoplasms, creating diagnostic difficulty in cytology specimens. We report proximal-type ES identified in cyst fluid from a lesion clinically interpreted as an epidermal inclusion cyst or abscess. A 43-year-old man presented with right thigh pain and a small cystic lesion on ultrasound. The fluid specimen was hypocellular and contained malignant epithelioid to rhabdoid cells with marked atypia, prominent nucleoli, and focal perinuclear clearing. Tumor cells expressed keratins and showed complete loss of INI1/SMARCB1, while claudin-4, MOC31, desmin, and SOX10 were negative. A concurrent core biopsy confirmed proximal-type ES. This case expands the recognized cytologic spectrum of proximal-type ES and highlights that a hypocellular cyst fluid specimen may nevertheless provide diagnostically useful material when morphology is integrated with a focused immunohistochemical panel.
Source: Diagnostic Cytopathology
DOI: 10.1002/dc.70210
Authors: Nathan McGrath, Azfar Neyaz, Samer Khader
Institution: University of Pittsburgh Medical Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,920
OpenAlex ID: W7211994809