EspF acts as a molecular scaffold to facilitate TRIM25-mediated NLRP3 inflammasome activation during mycobacterial infection
Year: 2026
Type: article
Abstract: BCG strains overexpressing EspF exhibited exacerbated lung lesions, increased inflammatory cell infiltration, and higher bacterial burdens. Collectively, these findings reveal EspF-TRIM25-NLRP3 axis is a novel mechanism of mycobacterial pathogenesis that drives hyperinflammation to facilitate bacterial survival and dissemination.
Source: Virulence
Authors: Yang Yang, Yixin Han, Longjian Wu, Xinxin Zang, Wei Xu, Yunjie Li, Ahui Xu, Hexiang Jiang, Jingyan Fan, Luqing Cui, Bei Huang, Guiqing He, Houhui Song
Institutions: Zhejiang A & F University, Wenzhou Medical University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,557
OpenAlex ID: W7212021914