Year: 2026
Type: article
Abstract: A study towards the undirected C-H fluorination and chlorination of cubane 1,4-diester is described using a user-friendly reagent such as Selectfluor and 1,3-dichloro-5,5-dimethylhydantoin under photoinduction. While the fluorocubane 1,4-diester is formed in low yield (8% yield) due to loss of material, the chlorocubane 1,4-diester was on the other hand prepared in 59% yield without the need for any photocatalyst. Moreover, a proof-of-concept of the chlorination of this strained scaffold was demonstrated using flow technology.
DOI: 10.3762/bjoc.22.101
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
Funders: Indian National Science Academy, Agence Nationale de la Recherche, Fonds Wetenschappelijk Onderzoek, Centre National de la Recherche Scientifique, Université de Rouen, Vlaamse regering, Institut Carnot Santé Animale, Région Normandie, European Regional Development Fund, XL-Chem Graduate School of Research
Awards: G1576599217, G1970702937, G2900821844, G4222807219, G4356253665, G4656594441, Fluorinations with implications: enhancing the potential of biologically and medicinally interesting molecules through targeted fluorine introduction, G5976147578, G5981856648, Synthèse Organique : des molécules au vivant, G799363536, Taming and Exploiting the Reactivity of Cubanes
OpenAlex ID: W7212031265