Work

Bacterial serine protease EspP induces differentiation and expansion of enteroendocrine cells in human colonoids

Year: 2026

Type: article

Abstract: can mimic the intestinal pathophysiology of EHEC in the absence of the bacteria. Using single-cell RNA sequencing, this study identified enteroendocrine cells as early responders to EspP treatment, with preferential hyperplasia of enterochromaffin cells. EspP-induced enteroendocrine cells also expressed immune cytokines and chemokines. This highlights the importance of enteroendocrine cell responses to bacterial pathogens and intestinal pathophysiology during infection.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00094.2026

Authors: Myranda N. Thompson, Ruixuan Liu, Cristina N. Coffman, Allison M. Kilpatrick, Lito L. Appell, Roger Atanga, Julie G. In

Institutions: University of New Mexico Health Sciences Center, University of Arizona

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: AGA Research Foundation, American Gastroenterological Association, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: G1849608474, Biology of Infectious Disease and Inflammation, G9000005190, G9000076288, G9000078449, G9000110561, G9000160631, Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.

OpenAlex ID: W7212040382

FWCI:

Cites: 55

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