Figure 1 from Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer
Year: 2026
Type: other
Abstract: Association of KIF18A expression with CIN in SCLC. A, Box plot showing the FGA scores across different lung cancer subtypes, including lung adenocarcinoma (LUAD, n = 518) and LUSC (n = 500) from The Cancer Genome Atlas (TCGA) database (30), and SCLC (n = 58) from George and colleagues (3). B, Box plots showing CES (left; ref. 28) and CIN70 gene signature (right; ref. 29) using TCGA (30) and George and colleagues datasets. C, Box plot showing KIF18A transcript levels across lung cancer subtypes in TCGA and George and colleagues datasets. D, Scatter plots showing the relationship between KIF18A transcript levels and CES (left) and CIN70 (right), across SCLC tumors from the George and colleagues dataset. E, Scatter plots showing correlations between KIF18A expression and proliferation markers PCNA (left) and MKI67 (right) in the George and colleagues dataset. F, Box plots showing KIF18A transcript levels across molecular subtypes of SCLC (ASCL1, NEUROD1, POU2F3, and YAP1) in the George and colleagues dataset. P values in A–C and F were calculated using two-sided Wilcoxon tests. Correlations in D and E were assessed using Spearman rank correlation. ns, not statistically significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. TPM, transcripts per million.
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7212047884