Frontline-worker infections as a marker of infection-prevention stress during the 2026 Bundibugyo virus disease outbreak in the Democratic Republic of the Congo
Year: 2026
Type: preprint
Abstract: Objective To quantify the reported burden, temporal contribution, mortality and health-zone distribution of frontline-worker infections during the 2026 Bundibugyo virus disease (BVD) outbreak in the Democratic Republic of the Congo, and to examine contemporaneous infection-prevention-and-control (IPC) evidence. Methods We conducted a retrospective longitudinal analysis of DRC situation reports, the INRB-UMIE BDBV2026-Data repository, and WHO outbreak updates, per STROBE principles. National health-worker snapshots were reconstructed for 10 June-9 August 2026; detailed Ituri Province tables were analysed for 13 July-4 August. Crude case fatality among frontline and other confirmed cases was compared using risk ratios and a stratified Mantel-Haenszel odds ratio. Findings Nationally, health-worker infections rose from 16/676 confirmed cases (2.4%) on 10 June to 151/3,605 (4.2%) on 30 July, contributing 11.0% of newly accumulated cases in the first three weeks but only 2.2-2.6% thereafter. Reported case fatality was lower among health workers, nationally on 30 July (29.1% versus 44.7%; risk ratio 0.65, 95% CI 0.51-0.84) and in Ituri on 4 August (30.7% versus 42.8%; RR 0.72, 95% CI 0.56-0.92; stratified odds ratio 0.59, 95% CI 0.41-0.85). Burden was spatially concentrated but heterogeneous across health zones. IPC reports documented low facility scorecards, recurrent high-risk exposures, and inconsistent worker denominators. Conclusion Frontline-worker infections formed a substantial, front-loaded epidemic component and a visible IPC-stress marker, but aggregate data cannot establish occupational incidence or place of acquisition. Lower reported mortality likely reflects earlier recognition or care access rather than lower severity. Standardized worker denominators and linked occupational surveillance should be incorporated into Ebola situation reporting. What was already known on this topic Previous Ebola and Marburg outbreaks have demonstrated substantial health-worker involvement, with infections linked to inadequate triage, insufficient personal protective equipment, exposure to patients with unrecognized infection and fragile health systems. Occupational burden is often concentrated early in epidemics, and infections among health workers can disable essential services, erode workforce confidence and signal weaknesses in infection prevention and control. However, routine outbreak reports rarely document health-worker trajectories in detail or link them systematically to IPC performance. What this paper adds Using reconciled longitudinal national and provincial snapshots and detailed personnel de premiere ligne (PPL) tables from Ituri Province, this paper quantifies the reported burden, mortality and health-zone distribution of frontline-worker infections during the 2026 BVD outbreak. It shows that frontline infections formed a substantial, front-loaded component of the epidemic and remained a visible marker of IPC stress, while crude case-fatality ratios among frontline workers were lower than among other confirmed cases. It demonstrates that available aggregate data cannot establish occupational incidence or place of acquisition, and argues that standardized worker denominators and linked occupational surveillance should be incorporated into Ebola situation reporting.
Source: medRxiv
Institution: University of Kinshasa
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7212059718