Work

Specific basal ganglia, amygdala, and cortical neurons are associated with borderline personality disorder (BPD)

Year: 2026

Type: preprint

Abstract: Borderline personality disorder (BPD) is clinically significant and poorly understood biologically. We tested which human brain cell types preferentially use genes associated with BPD, implicating two major types of neurons: LAMP5 interneurons and D2 medium spiny neurons. These interrogable cell types provide new avenues for investigating the neurobiology of BPD.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.09.04.749244

Authors: Hazal Senturk, Hadar Segal-Gavish, Jason Tucciarone, Laramie Duncan

Institution: Stanford University

Language: English

Topic: Personality Disorders and Psychopathology

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Broad Institute, National Institute of Mental Health, Stanford Maternal and Child Health Research Institute