Work

No significant changes in synaptic density and gray matter volume following motor learning—a pilot study

Year: 2026

Type: article

Abstract: In animal neurophysiology, motor learning induces long-term potentiation- and depression-like plasticity. In humans, gray matter volume (GMV) changes, measured non-invasively by MRI, in response to motor learning are interpreted as a surrogate measure of plasticity. Here we measure synaptic density with positron emission tomography (PET) to investigate the learning-induced synaptic plasticity more directly, and MRI-based GMV to investigate structural plasticity. In this pilot study, twenty-two volunteers participated in a simple or complex (group factor) four-week motor training on a bimanual tracking task. Learning progress was modelled individually. [ 18 F]SynVesT-1 PET and T1-weighted MRI were acquired at baseline (PRE) and immediately after the motor training (POST), and at MID for MRI only (time factor). Average standard uptake value ratios (SUVR), GMV and average cortical thickness in six a priori chosen VOIs of the visuomotor network were statistically compared over time, group and time-by-group, and associated with learning. Participants’ performance improved significantly, and more for the complex than the simple training group. The VOI-based PET and GM analyses did not yield any significant results. In this pilot study, we did not identify significant changes in [ 18 F]SynVesT-1 synaptic density as a surrogate marker for plasticity after motor learning in the a priori chosen VOIs.

Source: npj Science of Learning

DOI: 10.1038/s41539-026-00451-5