Additional file 1 of Validating the biological origin of in vivo fractional intracellular volume from VERDICT-MRI in the prostate
Year: 2026
Type: article
Abstract: Additional File 1: Table S1. Distribution of b-values used for calculation of ADC maps in clinical mpMRI. Table S2. Distribution of field strengths used for clinical mpMRI. Table S3. Comparison of correlations between MRI-derived metrics and histological tissue measures using Williams-modified Hotelling t-tests. Fig. S1. Representative example: a 67-year-old man with prostate-specific antigen levels of 10.89 ng/mL at referral, prostate volume of 36 mL and Likert Score 3. WSI (left) and corresponding masked MRI and histologically derived maps (fIC, fEES, fVASC and R from VERDICT-MRI; cell density, epithelial cell density and epithelial fraction from histology). fEES, Fractional extracellular extravascular space; fIC, Fractional intracellular volume; fVASC, Fractional vascular volume; R, Radius; VERDICT Vascular, extracellular, and restricted diffusion for cytometry in tumors; WSI, Whole-slide imaging. Fig. S1. Representative example: a 67-year-old man with prostate-specific antigen levels of 10.89 ng/mL at referral, prostate volume of 36 mL, and Likert Score 3. WSI (left) and corresponding masked MRI and histologically derived maps (fIC, fEES, fVASC and R from VERDICT-MRI; cell density, epithelial cell density and epithelial fraction from histology). fEES, Fractional extracellular extravascular space; fIC, Fractional intracellular volume; fVASC, Fractional vascular volume; R, Radius; VERDICT, Vascular, extracellular, and restricted diffusion for cytometry in tumors; WSI, Whole-slide imaging.
Source: Figshare
Authors: Marta Masramon, Manju Mathew, Saurabh Singh, Thomy Mertzanidou, Joey Clemente, Adam Retter, Natasha Thorley, Adam Phipps, Thomas Parry, Marianti-Vasiliki Papoutsaki, Lorna Smith, Francesco Grussu, Veeru Kasivisvanathan, Alistair Grey, Eoin Dinneen, Greg Shaw, Dominic Patel, Lucy Caselton, Caroline M. Moore, David Atkinson, Aiman Haider, Alex Freeman, Daniel C. Alexander, Shonit Punwani, Eleftheria Panagiotaki
Language: English
Topic: MRI in cancer diagnosis
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7212126280