Year: 2026
Type: article
Abstract: While the immuno-modulatory effects of lactic acid bacteria (LAB) on conventional T cells are well documented, their effects on unconventional T cells, including gamma-delta (γδ) T cells, have not yet been fully characterized. Here, we show that LAB can generate regulatory γδ T cells by significantly increasing interleukin (IL)-10 production relative to stimulation with methicillin-resistant Staphylococcus aureus (MRSA), a pathogenic bacterial strain. This regulatory function subsequently attenuated inflammatory responses in intestinal epithelial cells and immune cells. Thus, LAB can induce regulatory functions in γδ T cells, which may contribute to the maintenance of intestinal health.
Authors: Zhenzi PENG, Alato OKUNO, Suguru SAITO
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: diamond
Awards: Development of a novel approach for inhibition of nuclear translocation of HBV genomic DNA in infected cells, Peripheral regulation of central tryptophan metabolism in relation to psychiatric disorders, G6402983686, Suppression of brain inflammation through induction of endogenous anti-inflammatory compound by prebiotics and probiotics
OpenAlex ID: W7212130152