PADA‑V2: Axis Model of Photoperiod‑Adenosine‑A₂A Receptor Desensitization‑Aging Core Summary‑CN
Year: 2026
Type: preprint
Abstract: This is the English‑language concise standalone summary (Core Summary‑EN) for the PADA‑V2 hypothesis. PADA‑V2 (Photoperiod‑Adenosine‑A₂A Receptor Desensitization‑Aging) is a falsifiable theoretical hypothesis in sleep biology. Beyond the classical adenosine‑concentration‑centered framework, it introduces GRK‑mediated homologous desensitization of A₁/A₂A receptors as a second independent regulatory variable. This condensed summary presents core mechanisms, scientific contradictions, key inferences and fully testable animal‑experimental predictions. This is a derived summary manuscript. For full deductive logic, boundary conditions and supplementary materials please consult the complete archived English manuscript: https://doi.org/10.5281/zenodo.22070220. All content represents theoretical deductions without experimental validation. It is intended only for hypothesis archiving and experimental‑design reference and shall not be used for clinical diagnosis, therapy or self‑directed human physiological interventions.
Author: Ma, Billy
Language: Chinese
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7212132569
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