Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Background: Married men with prostate cancer (PCa) choose active treatment more often than unmarried men. However, the impact of sexual orientation or parental status on PCa treatment selection is unknown and may provide opportunities for improved counseling. Methods: We retrospectively studied the Merative™ Marketscan® Commercial Database between 2004–2022 for localized PCa among married men ≤ 65 years. The primary outcome was treatment selection one year after diagnosis. Multivariable regression evaluated associations between parental status or spousal sex and treatment selection. Results: Of 71,567 men, 99% had a female spouse and 58% did not have a child. Patients most-often chose prostatectomy (57%), then surveillance (18%) and radiation (15%). Men with children had greater odds of selecting observation/surveillance over prostatectomy (aOR:1.09;95%-CI:1.04–1.14;P < 0.001). Spousal sex did not impact treatment selection. Conclusions: Having children was associated with greater odds of choosing AS compared to prostatectomy in a national commercial health insurance claims database, suggesting that parental status may affect treatment selection in localized PCa among men aged ≤ 65.
Source: Research Square
Institution: University of Chicago
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7212153837