Work

SNAr-Functionalization of Diaryliodonium Salts: Access to Densely Substituted Arenes

Year: 2026

Type: article

Abstract: Diaryliodonium salts are efficient electrophilic arylation reagents for a wide variety of nucleophiles. The main limitation in the arylation scope is often the difficulty in synthesizing advanced heteroatom-functionalized diaryliodonium salts, due to their sensitivity to acidic and oxidative conditions. We present a general SNAr strategy to functionalize fluoro-substituted iodonium salts, which enables the synthesis of a wide range of heteroatom-functionalized iodonium salts, with demonstrated reactivity in a variety of transition-metal-free O-, N-, and S-arylations to provide densely functionalized aromatic products.

Source: JACS Au

DOI: 10.1021/jacsau.6c01053

Authors: Leonard Kersting, Judith Braunreuther, Erika Linde, Berit Olofsson

Institution: Stockholm University

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,500

Funders: Vetenskapsrådet, Stockholms Universitet, Erasmus+