Work

Divergent evolution in bilateral prostate cancer: a case study

Year: 2026

Type: article

Study design: Case Report

Abstract: Multifocal prostate cancer is a prevalent phenomenon, with most cases remaining uncharacterized from a genomic perspective. A patient presented with bilateral prostate cancer. On systematic biopsy, two indistinguishable clinicopathologic lesions were detected. Whole-genome sequencing displayed somatically unrelated tumors with distinct driver CNA regions, suggesting independent origins of the two tumors. We demonstrated that similar clinicopathologic multifocal tumors, which might be interpreted as clonal disease, can in fact represent independent cancers. Genetic prognostics can prevent mischaracterization of multifocal disease to enable optimal patient management.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1681073

Authors: Roni Haas, Yash Patel, Lydia Y. Liu, Rong Rong Huang, Adam Weiner, Takafumi N. Yamaguchi, Raag Agrawal, Paul C. Boutros, Robert E. Reiter

Institutions: University of California, Los Angeles, UCLA Jonsson Comprehensive Cancer Center

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801

Funders: U.S. Department of Defense, Prostate Cancer Foundation, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: INTEGRATED META-ANALYSIS OF PROSTATE CANCER GENOMES, G2341660198, G2567748467, G4107277101, G438339894, G4658865915, UCLA-Caltech Medical Scientist Training Program, THE ROLE OF GENOMIC DIVERSITY IN CLINICALLY HIGH-RISK PROSTATE CANCER, G7432761054, G7527623273, G9000097764, G9000276237, Cancer Center Support Grant, Virginia-UCLA-Toronto Biomarker Characterization Center

OpenAlex ID: W7212180230

FWCI:

Cites: 27

Cited by:

Related to: