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Machine learning optimization of polymeric complex coacervate micelles reveals cell-type-specific formulations for enhanced mRNA delivery

Year: 2026

Type: article

Abstract: Machine learning guided optimization of mixed micelle composition enhanced mRNA delivery across diverse cell lines and identified formulation features that govern delivery and viability, revealing cell specific design rules.

Source: Chemical Science

DOI: 10.1039/d6sc05905h

Authors: Sidharth Panda, Theresa M. Reineke

Institution: University of Minnesota

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: University of Minnesota, National Institutes of Health

Award: Bespoke Micellar Nanoparticles (MNPs) for In Vivo Delivery of Digital Base Editor Treatments for Primary Immunodeficiency Disease

OpenAlex ID: W7212180461

FWCI:

Cites: 47

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Related to: 10