Work

Fe III ‐Mediated Synthesis of Azaspirodienones via Ipso ‐Radical Cyclization of Ugi–4CR Adducts

Year: 2026

Type: article

Abstract: A concise and operationally simple two‐step protocol for the efficient synthesis of azaspirodienones through Fe III ‐mediated ipso ‐radical cyclization of Ugi adducts has been developed. The strategy combines the versatility of multicomponent Ugi reactions with the synthetic power of radical cyclization, enabling rapid construction of structurally complex and medicinally relevant spirocyclic frameworks from readily accessible starting materials.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70846

Authors: Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García

Institution: Universidad Nacional Autónoma de México

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funders: Universidad Nacional Autónoma de México, Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México