Clinical Application of Hemadsorption in Maintenance Hemodialysis Patients: An Adapted English Republication of the Chinese HA-MHD Consensus
Year: 2026
Type: review
Abstract: The accumulation of protein-bound uremic toxins and middle- to large-molecular-weight toxins in patients receiving maintenance hemodialysis (MHD) results in long-term complications. Hemadsorption (HA) can efficiently remove these uremic toxins and reduce the risk of long-term complications in MHD patients. The Chinese HA-MHD Consensus Working Group has revised and updated the 2021 Shanghai Expert Consensus on the Clinical Application of Haemoadsorption in Maintenance Haemodialysis Patients to further standardize clinical application of HA and reflect the latest evidence. Based on an extensive literature search, the Grading of Recommendations Assessment, Development and Evaluation framework, and the modified Delphi method, the working group formulated 27 evidence-based recommendations regarding patient populations, session frequency, treatment modalities, precautions, and adverse reactions. This consensus systematically delineates the clinical thresholds and rationales for utilizing HA across three core dimensions: routine treatment regimens, intensive treatment regimens, and long-term complication risk management to provide comprehensive guidance. Furthermore, the consensus provides detailed guidance on individualized operational parameters to maximize both safety and treatment efficacy. This consensus aims to provide the latest guiding opinions for the rational and standardized application of HA therapy in patients receiving MHD.
Source: Kidney Medicine
Authors: Xiaohua Sheng, Wei Lu, Zhiyong Guo, Shan Mou, Zhaohui Ni, Xiaoqiang Ding, Yueyi Deng, Guisen Li, Jun Liu, Pengli Luo, Shiren Sun, Huiming Wang, Jiali Wei, Xudong Xu, Xiangdong Yang, Zhenhua Yang, Wen Zhang, Jianrong Zhao, Xiaoling Zhou, Xiaoshuang Zhou, Zhu Zhou, Gengru Jiang, Niansong Wang
Institutions: Shanghai Jiao Tong University, Shanghai Sixth People's Hospital, XinHua Hospital, Second Military Medical University, Renji Hospital, Fudan University, Zhongshan Hospital, Shanghai University of Traditional Chinese Medicine, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Shanghai First People's Hospital, Qinghai University Affiliated Hospital, Xijing Hospital, Air Force Medical University, Renmin Hospital of Wuhan University, Hainan General Hospital, Shandong University, Qilu Hospital of Shandong University, First Affiliated Hospital of GuangXi Medical University, Ruijin Hospital, Inner Mongolia Medical University, Ningxia Medical University General Hospital, Shanxi Provincial People’s Hospital, First Affiliated Hospital of Kunming Medical University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funders: Shandong University, National Natural Science Foundation of China, Fudan University, Shanghai Jiao Tong University, Qinghai University, Shanghai University of Traditional Chinese Medicine, Guangxi Medical University, Ruijin Hospital, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, National Key Research and Development Program of China, Renmin Hospital of Wuhan University
Awards: G6227827358, G6330803280
OpenAlex ID: W7212229116