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Initial Construct Validation of the Mito Map Energy Score Against a Composite Functional Measure

Year: 2026

Type: preprint

Abstract: Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants. The Energy Score was strongly associated with the Measured Function Score (Pearson r = 0.907; 95% CI 0.781 to 0.962), with supporting rank-correlation, leave-one-out, objective-only, protocol, and agreement analyses. These findings support initial convergent construct validity but do not establish diagnostic validity, clinical utility, or prospective prediction. The accompanying publication package contains aggregate results and de-identified figures only; it contains no direct identifiers or row-level participant records.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.22713519

Author: Friedl, Andrew

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7212235147

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