Work

Unlocking the Potential of Organoaluminum Reagents for Versatile C─C Couplings Using YPhos‐Pd Catalysts

Year: 2026

Type: article

Abstract: We report a general and efficient protocol for the palladium-catalyzed cross-coupling of aryl chlorides with a broad range of organoaluminum nucleophiles, enabled by strongly donating ylide-functionalized phosphines (YPhos). Unlike other earthabundant organometallic reagents, the protocol demonstrates broad functional group tolerance, even allowing for late-stage functionalizations of complex molecules. In general, high selectivities and yields are achieved, while maintaining the high reactivity characteristics of this class of compounds even at room temperature. The presented protocol highlights the key advantages of this thus far underestimated class of nucleophiles in coupling chemistry and illustrates both the strengths and limitations of in situ generated alkyl-, aryl-, alkenyl-, and alkynylaluminum reagents.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70757

Authors: Nicolas Kaiser, Julius Busse, Ben Wichmann, Viktoria H. Gessner

Institution: Ruhr University Bochum

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funders: Deutsche Forschungsgemeinschaft, European Research Council