The effects of repetitive transcranial magnetic stimulation on executive functions in healthy and at-risk older adults: a systematic review and meta-analysis
Year: 2026
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: Cognitive flexibility, inhibitory control, and working memory are core executive functions and early vulnerable cognitive domains across the continuum from healthy aging to mild cognitive impairment, highlighting the need for preventive interventions before substantial neurodegeneration occurs. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique inducing lasting changes in cortical excitability and network-level plasticity. Accordingly, this systematic review and meta-analysis examined the effects of rTMS, with or without behavioral training, on these core executive functions in healthy older adults and individuals at increased risk of dementia. Five electronic databases were searched for randomized controlled and crossover trials up to September 2025. Eligible studies involved rTMS in healthy older adults, individuals with subjective cognitive decline, or mild cognitive impairment aged ≥ 55 years. Effect sizes were calculated as Hedges’ g with 95% confidence intervals. Random-effects models used the DerSimonian–Laird estimator, whereas fixed-effect models were applied when heterogeneity was low. Methodological quality was assessed using the Physiotherapy Evidence Database scale. Seventeen studies involving 497 participants were included. Compared with sham conditions, rTMS showed small but statistically significant immediate effects on cognitive flexibility (Hedges’ g = 0.31, p = .049) and working memory (Hedges’ g = 0.30, p = .049), whereas no significant immediate effect was observed for inhibitory control. At follow-up, a significant effect was observed for cognitive flexibility (Hedges’ g = 0.33, p = .036). Subgroup analysis yielded a large effect estimate for high-frequency bilateral dorsolateral prefrontal cortex stimulation (DLPFC) on cognitive flexibility (Hedges’ g = 0.96, p = .001); however, this finding was based on only two studies. Available neuroimaging evidence provided preliminary indications of changes in frontoparietal and salience-network activity following high-frequency right or bilateral DLPFC stimulation. rTMS, with or without behavioral training, may modestly improve cognitive flexibility and working memory in healthy and at-risk older adults, with cognitive flexibility also showing a small follow-up effect. High-frequency bilateral DLPFC stimulation may represent a promising protocol for cognitive flexibility, although this subgroup finding requires prospective confirmation. Future studies should compare stimulation parameters, intervention approaches, and network-guided targeting strategies to determine optimal configurations for specific executive domains.
Source: Alzheimer s Research & Therapy
Institutions: Hong Kong Polytechnic University, National Taiwan University
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,290
OpenAlex ID: W7212355468
FWCI:
Cites:
Cited by:
Related to: