Year: 2026
Type: preprint
Abstract: The Big 5 personality traits (extraversion, agreeableness, conscientiousness, neuroticism, openness to experience) are moderately heritable correlates of behavior, health, and life outcomes. Characterizing childhood expressions of genetic variation associated with adult personality may inform our understanding of personality development and how personality becomes associated with behaviors and environments. Our phenome-wide association study (PheWAS) of Big 5 polygenic indices (PGIs) among children (n European-like ancestry =5,556; n African-like ancestry =1,584) in the Adolescent Brain Cognitive Development Study SM (ABCD Study®) across ages 9-11 and 11-13 revealed stable associations between neuroticism PGI and measures of child mental health, openness PGI and cognition, agreeableness PGI and externalizing behaviors, conscientiousness PGI and perseverance, and extraversion PGI and impulsivity. Longitudinal analyses indicated stronger personality PGI associations with some phenotypes (e.g., prosocial behavior) at ages 11-13. Behavioral correspondence to genetic propensity to adult personality is evident in early adolescence while certain correlates of personality PGIs may only manifest later in development.
Source: medRxiv
Authors: Margaret L. Clapp Sullivan, Alex P. Miller, Emma C. Johnson, Nicole R. Karcher, Sarah E. Paul, Joshua J. Jackson, Ryan Bogdan, Arpana Agrawal
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G1569016918, G3755973507, G8281824583, G9000006386, G9000008241, G9000034221, G9000041532, G9000108491, G9000112882, G9000163168, G9000200779, G9000205938, G9000241459, 9/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN, Neurogenetic influences linking impulsive personality traits and alcohol use disorder progression across development, Neurobehavioral pathways of polygenic and polyenvironmental effects on the onset and maintenance of substance involvement, 8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA, 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU, Predicting Attenuated Psychotic Symptoms Amongst Youth Endorsing Persistent Distressing Psychotic-like Experiences, 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB
OpenAlex ID: W7212373550
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