Feasibility and efficacy of personalized cardiorespiratory and strength exercise in Duchenne muscular dystrophy: a pilot study
Year: 2026
Type: preprint
Study design: Clinical Trial
Abstract: ABSTRACT Background Duchenne muscular dystrophy (DMD) results from absence of dystrophin, causing sarcolemmal instability, progressive muscle and mitochondrial dysfunction and reduced cardiorespiratory fitness and bone density. Exercise may target these multisystem abnormalities but remains underutilized due to historical safety concerns and lack of disease-specific guidelines for optimal dosing. We conducted an exploratory trial using personalized exercise prescription to assess adherence, safety and preliminary efficacy in DMD. Methods Six ambulatory boys underwent 6-months of home-based, remotely-supervised leg cycling and isometric strengthening using individualized frequency, intensity and time parameters. Cycling was set to 40-60% of heart rate and strengthening to 50% maximal voluntary contraction (MVC). Safety was assessed by creatine kinase (CK), muscle MRS T 2 , and adverse events. Primary outcomes were 6-month change in peak oxygen uptake (VO₂) and submaximal-cycling HR; secondary outcomes included muscle fat fraction, cross-sectional area (CSA) and peak strength; exploratory outcomes included bone density, pulmonary function and quality-of-life. Peak VO 2 and CSA were contextualized against untreated DMD controls. Results All participants completed the intervention with high adherence (88.5%) and no adverse events. Cycling averaged 2-3 times/week at HR 148 + 8 bpm for 21.9 + 3.9 minutes; strengthening averaged 1.8 + 0.6 sessions/week at 50% MVC. CK and MRS T 2 remained stable. Peak VO₂ and submaximal-cycling HR improved, CSA increased relative to controls, and hamstring strength increased. Bone density, forced vital capacity and quality-of-life scores showed favorable trends. Discussion Appropriately dosed exercise is feasible, safe and may produce multisystem physiological benefits in boys with DMD, supporting personalized, physiologically monitored training as a complementary therapeutic strategy. Trial registry name and number: Exercise as Therapy for DMD; NCT04322357
Source: medRxiv
Authors: Meghana Bomma, Donovan Lott, Sean Forbes, Victoria Del Toro, Diego Maldonado-Puebla, Mallory Paul, Ruby Sullivan, Andrew Carvill, Aiden Foy, Renata Shih, John Anthony Coppola, Carmen Leon-Astudillo, Glenn Walter, Michael Daniels, Kimberly Stubbs, Warren Dixon, H. Lee Sweeney, Tanja Taivassalo
Institutions: University of Florida, University of Florida Health
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7212383297