Work

Epithelioid Fibrous Histiocytoma With Bulbous Subcutaneous Extension and SQSTM1 :: ALK Fusion

Year: 2026

Type: article

Abstract: IntroductionEpithelioid fibrous histiocytoma (EFH) is a histopathologically distinct benign cutaneous neoplasm characterized by ALK rearrangement resulting in aberrant anaplastic lymphoma kinase (ALK) expression detectable by immunohistochemistry [1,2].Classically, EFH is composed of epithelioid cells arranged as a dome-shaped nodule in the superficial dermis with an epidermal collarette.Large case series have characterized a fairly narrow spectrum of histopathologic features with nearly all cases confined to the dermis [2-5].Recently in this journal, Dileep et al. reported three cases of EFH with deep dermal and subcutaneous extension [6].Herein, we report an epithelioid fibrous histiocytoma with deep subcutaneous extension and diagnosis further supported by detection of a SQSTM1::ALK fusion by next generation sequencing studies.

Source: Journal of Cutaneous Pathology

DOI: 10.1111/cup.70201

Authors: Hannah Moorman, Jennifer Crimmins, Joseph Gillam, Scott Turner, Mark C. Mochel

Institutions: Virginia Commonwealth University, Virginia Commonwealth University Medical Center, Duke University Hospital

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,570