Computational Peptide Design Methods for Drug Discovery Targeting Protein-Protein Interactions
Year: 2024
Type: dissertation
Abstract: Drug discovery targeting protein-protein interactions (PPIs) has attracted much attention and has potential applications in several disease areas.Various modalities have been explored in PPI drug discovery.The physicochemical properties of the broad and shallow PPI interface are different from those of a typical ligand pocket, making it difficult to design effective PPI drugs with small molecule compounds.In addition, antibodies cannot target intracellular proteins, cannot be orally administered, and are moreover more costly to manufacture.Therefore, peptides are attracting attention as a PPI targeting modality as molecules that have properties of both small molecules and antibodies.The peptides are composed of 20 amino acids and have the advantage of binding to broad and shallow PPI interface.Peptides have also been developed that have various physical properties I would like to express my sincere gratitude to Associate Professor Masahito Ohue for providing me with an excellent research environment and for his continuous guidance and encouragement throughout my research work.I also wish to thank all members of Ohue laboratory for their helpful discussions and the wonderful time we spent together.A special thanks to our lab member, Apakorn Kengkanna, for their meticulous review and helpful comments on this doctoral thesis.Their insights
Author: Takatsugu Kosugi
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7212460505