TABASCO: A single molecule, base-pair resolved gene expression simulator-5
Year: 2011
Type: other
Abstract: Copyright information:Taken from "TABASCO: A single molecule, base-pair resolved gene expression simulator"http://www.biomedcentral.com/1471-2105/8/480BMC Bioinformatics 2007;8():480-480.Published online 19 Dec 2007PMCID:PMC2242808. creation of implicit rules defined by the state of protein-DNA interactions and of the DNA itself. For example, when a traversing polymerase occupies a genetic element such as a protein-DNA binding site (a), the binding site is inactivated and prevented from binding a protein until the polymerase completely clears the site. Activation of genetic elements by entry of DNA into the cell (b) and inter-polymerase interactions (c) can be directly simulated as well. Finally, in complex genetic environments (d) where multiple promoters and terminators regulate the expression of genes, a priori transcription levels for each protein need not be calculated, for they are generated implicitly.
Source: Figshare
Authors: Sriram Kosuri, Kelly, Jason R, Endy, Drew
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7213071255