Figure 2 from Supermeres Containing the Discoidin Domain Receptor 1 Extracellular Domain Promote Collagen Alignment and Immune Exclusion in Microsatellite-Stable Colorectal Cancer
Year: 2026
Type: other
Abstract: Stromal genes associated with DDR1 and collagen alignment in colorectal cancer. A, Schematic of CASTA. B, Representative whole-section 2HG image of patient 1 tumor sample. Scale bars, 1 mm (left) and 400 μm (insets). C, Representative collagen coherence heatmap of patient 1 tumor sample. D, Pirate plot of collagen coherence in stromal and epithelial spots. Each point is one Visium spot. ****, P < 0.0001. E, Correlation of each gene with stromal collagen coherence and DDR1 expression in adjacent epithelium. Positively correlated genes with an adjusted P < 0.05 highlighted in blue. F, Gene Ontology terms of genes identified in E. Contraction-related ontologies in bold. G, Overlap of stromal genes correlated with DDR1 expression in two or more samples. H, Gene Ontology terms of stromal genes correlated with DDR1 in two or more samples. Contraction-related ontologies in bold. Patient data in Supplementary Table S1.
Authors: Maxwell S. Hamilton, Samuel T. Ellis, Zheng Cao, Oleg S. Tutanov, Alan J. Simmons, Radhika Aramandla, James N. Higginbotham, Marisol Ramirez, Katherine W. Schnee, Matthew E. Bechard, Harsimran Kaur, Jeffrey L. Franklin, Swastika Mandal, Ken S. Lau, Qi Liu, Jeremy A. Goettel, Ambra Pozzi, Robert J. Coffey
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7212600158
Cites:
Cited by:
Related to: