Work

Pt( iv ) scaffold effects on nucleolar stress and DNA damage response pathways

Year: 2026

Type: article

Abstract: values reveals that lipophilicity alone does not fully account for biological activity. Notably, we identify the most potent nucleolar stress inducer reported, a Pt(iv) compound requiring ∼1000-fold lower concentrations to trigger nucleolar stress than the DACH-Pt(ii) analogue. Together, these findings establish Pt(iv) ligand design as a strategy to optimize antiproliferative activity while selectively intensifying DDR or nucleolar stress.

Source: RSC Chemical Biology

DOI: 10.1039/d6cb00235h

Authors: Christopher R. Griffin, Victoria J. DeRose

Institution: University of Oregon

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962