Work

Late-Onset Neonatal Cyanosis Secondary to Methemoglobinemia in a Preterm, Small-for-Gestational-Age Infant: A Case Report

Year: 2026

Type: article

Abstract: Methemoglobinemia is a rare cause of neonatal cyanosis stemming from hemoglobin iron oxidation, creating susceptibility due to immature enzymatic systems in newborns. This case study details a 32-week preterm infant presenting with unexplained desaturations (oxygen saturation (SpO2): 82-90%) on day of life 13, which were resolved with intravenous methylene blue and oral vitamin C after co-oximetry confirmed 18% methemoglobin. Prompt diagnosis and low-dose targeted therapy are essential for managing this condition in fragile, preterm neonates with persistent central cyanosis.

Source: Cureus

DOI: 10.7759/cureus.116196

Authors: Pooja Patel, Dipika Bhil

Institution: Suamandeep Vidyapeeth University

Language: English

Topic: Methemoglobinemia and Tumor Lysis Syndrome

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7212776960