Work

Analysis code for "Whole brain cellular activation after mu and NOP receptor agonism identifies differential regional and network consequences"

Year: 2026

Type: software

Abstract: Analysis code for "Whole brain cellular activation after mu and NOP receptor agonism identifies differential regional and network consequences". R scripts covering the full pipeline: preprocessing and region cleaning of NeuroInfo exports, regional statistical models (one-way ANOVA on log10 density with Benjamini-Hochberg correction, sex-stratified and two-way models, and negative-binomial and globally normalised sensitivity analyses), interregional co-activation network construction and analysis (proportional thresholding at matched density, consensus-Louvain module detection, cartographic node roles, global metrics with bootstrap and permutation inference), and the figure-generation scripts. All stochastic procedures run under fixed random seeds, so the deposited code reproduces the reported values exactly. See readme.md for run order and dependencies.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.22755395

Authors: Martinez, Madeline, Ozawa, Akihiko, Van Zant, Daniel, Thornberry, Jake, Toll, Lawrence

Institution: Florida Atlantic University

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke