Figure 4 from Supermeres Containing the Discoidin Domain Receptor 1 Extracellular Domain Promote Collagen Alignment and Immune Exclusion in Microsatellite-Stable Colorectal Cancer
Year: 2026
Type: other
Abstract: Coculturing DDR1-expressing DiFi spheroids with normal fibroblasts promotes CD8+ T-cell exclusion in 3D coculture. A–D, Representative merged DIC and epifluorescence images of CD8+ (A and B) and CD4+ (C and D) T cells (red, white arrowheads point to labeled T cells within spheroids) and pirate plots of average T-cell infiltration in DiFi spheroids after 24 hours. Scale bars, 25 μm. Each point is the average number of T cells per DiFi spheroid in a single dome. ns, not statistically significant; **, P < 0.01. N = 9 domes.
Authors: Maxwell S. Hamilton, Samuel T. Ellis, Zheng Cao, Oleg S. Tutanov, Alan J. Simmons, Radhika Aramandla, James N. Higginbotham, Marisol Ramirez, Katherine W. Schnee, Matthew E. Bechard, Harsimran Kaur, Jeffrey L. Franklin, Swastika Mandal, Ken S. Lau, Qi Liu, Jeremy A. Goettel, Ambra Pozzi, Robert J. Coffey
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7212944890
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