Work

Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans

Year: 2026

Type: article

Abstract: lifespan at lower doses, and that both compounds exert a toxic effect at higher doses, significantly shortening lifespan.

Source: PubMed Central

DOI: 10.17912/micropub.biology.002198

Authors: Erik Johnson, Christine A. Sedore, Anna L. Coleman-Hulbert, Brian D. Onken, Vijaya Madhuri Achanta, Yuhua Song, Gino Cortopassi, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, USAF Phillips Laboratory

Awards: Caenorhabditis Intervention Testing Program at Oregon, Caenorhabditis Intervention Testing Program: Interventions That Modulate Health, Longevity and Aging Hallmarks, Caenorhabditis Testing Program Data Coordinating Center, Caenorhabditis Intervention Testing Program - Buck Institute

OpenAlex ID: W7213096531

FWCI:

Cites: 20

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Related to: 10