Work

Synthesis of C1-quaternary 1-(α-methylbenzylamino)cyclobutane derivatives

Year: 2026

Type: article

Abstract: A small panel of non-racemic 1-(α-methylbenzylamino)cyclobutanes bearing one-carbon functional groups at C1 of the cyclobutane ring was targeted. Successful synthetic procedures were established to access the target molecules, with the exception of the C1-formyl derivative whose electrophilicity was incompatible with the free secondary amine. When a C1 nucleofugal group was generated, cyclization occurred leading to a novel spiroaziridine derivative.

Source: Tetrahedron Letters

DOI: 10.1016/j.tetlet.2026.156271

Authors: Stefano Barranco, Dianya Fu, Angelo Frongia, Sandrine Deloisy, David J. Aitken

Institutions: Centre National de la Recherche Scientifique, University of Cagliari, Université Paris-Saclay, Institut de Chimie Moléculaire et des Matériaux d'Orsay

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,610

Funders: Ministero dell'Università e della Ricerca, Ministero dell'Istruzione e del Merito