Work

Targeting Wnt signaling with Signalomics in primary breast cancer and gynecological pathologies

Year: 2026

Type: preprint

Abstract: Breast and gynecological pathologies, such as endometriosis and cancers, rely on aberrant activation of pro-proliferative pathways like Wnt signaling. In addition to multiple omics techniques utilized to identify drivers and targetable vulnerabilities in these diseases, Signalomics has recently emerged as a new tool to rapidly assess the levels of activation of oncogenic signaling pathways in primary cells. Here we demonstrate the power of Signalomics when applied to patients with breast, ovarian, and endometrial cancers, as well as endometriosis. Assessing basal and stimulated levels of Wnt signaling in patients’ surgical samples, we find these levels to correlate with the disease progression. We further show that pharmacological inhibition of the Wnt pathway in many of these primary samples suppresses cell proliferation, offering means for patient stratification prior to eventual targeted treatment. Altogether, our study is the first example of Signalomics applications in daily clinical settings, offering insights into disease mechanisms and personalized treatment.

Source: Research Square

DOI: 10.21203/rs.3.rs-10900657/v1