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Supplementary Figure S3 from Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk Neuroblastoma

Year: 2026

Type: supplementary-materials

Abstract: Supplementary Figure S3: DNA methylation analysis of neuroblastoma tumor samples reveals distinct methylation patterns. (A) Genome-wide DNA methylation levels were calculated in 7 neuroblastoma tumor gDNA and 3 PBL pools of 10 individuals each revealed globally reduced levels in neuroblastoma. Analysis is represented by violin plots with orange and white dots drawn at the distribution medians and means respectively. (B) Hierarchical clustering analysis based on methylation levels in neuroblastoma tumor and PBL pool samples reveal distinct molecular characteristics.

DOI: 10.1158/1078-0432.33776350

Authors: Nurit Gal-Mark, Assaf Grunwald, Valid Gahramanov, Michal Hameiri-Grossman, Elena Shinderman-Maman, Dafna Gaas, Keren Shichrur, Jacques Mordoukh, Nino Oniashvili, Eva Chausky Barzakh, Aviv Sever, Shirah Amar, Shifra Ash, Yehudit Birger, Shai Izraeli, Yuval Ebenstein, Esther R. Berko

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7213232050

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