Multi-omics and artificial intelligence for climate-resilient and nutrient-enriched food crops: advances, applications and future perspectives
Year: 2026
Type: article
Abstract: Climate change has intensified both abiotic and biotic stresses, threatening global crop productivity, nutritional quality, and agricultural sustainability. These challenges have accelerated the adoption of advanced multi-omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, together with artificial intelligence (AI) to accelerate the development of climate-resilient and nutrient-enriched crops. This review provides an integrated view of the recent advances in AI-enabled multi-omics, genome editing and precision agriculture for climate-resilient and nutrient-rich crops along with emerging trends, current challenges, and future research priorities. Machine learning-enhanced genomic selection approaches such as convolutional neural network (CNN)-based models and transformer models enhance the accuracy of predictions for complex stress-tolerant and nutritional traits. AI-assisted unmanned aerial vehicle (UAV) remote sensing allows measurement of traits at an unprecedented scale and with high-throughput and quantitative phenotyping. AI-driven multi-omics integration approaches, such as pan-omics pipelines, decipher abiotic stress tolerance regulatory networks. The AI-assisted CRISPR-Cas9 genome editing systems have accelerated crop biofortification outcomes by improving target prioritization and guide RNA design. Genome-editing studies have reported enhanced iron and zinc bioavailability in experimental wheat lines, reduced phytic acid content in soybean, and enhanced vitamin and amino acid content in cassava and maize, highlighting the potential of AI-assisted genome-editing approaches for crop biofortification. AI-enabled precision agriculture platforms use AI together with satellite data and Internet of Things (IoT) sensors and predictive modeling to enhance crop management while decreasing environmental resource usage. This review examines data standardization and model interpretability together with access and regulations while it presents a future roadmap for achieving 2050 food security targets. By integrating multi-omics, artificial intelligence, genome engineering, and precision agriculture into a unified framework, this review identifies future research directions and key knowledge gaps for the development of climate-resilient and nutrient-rich crops.
Authors: Surasreeta Paul, Sandeep Singh Rana
Institution: Vellore Institute of Technology University
Language: English
Topic: Smart Agriculture and AI
Subfield: Plant Science
Domain: Life Sciences
SDGs: Zero hunger, Climate action
Open Access status: gold
Estimated APC paid: $2,353
OpenAlex ID: W7213241547