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Electrosynthesis of Bis-spirocycles via a Radical Strain-Release Dearomatization Cascade

Year: 2026

Type: preprint

Abstract: This report presents an electro-oxidative approach to synthesize functionalized bis-spirocycles by combining the strain-release reactivity of bicyclo[1.1.0]butanes (BCBs) with arene dearomatization in a radical cascade. Various radical precursors can undergo this transformation under mild, oxidant- and mediator-free conditions, allowing efficient production of complex, three-dimensional bis-spirocyclic structures with high functional-group tolerance. Mechanistic investigations indicate an anodically driven radical cascade, involving radical addition to the BCB, strain-release ring opening, and subsequent ipso-dearomatization.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15008903/v1

Authors: Pooja Bhardwaj, Braja Kishor Paul, Padmanabha Samanta, Pintu Kumbhakar, Aritri Saha, Suman De Sarkar

Institution: Indian Institute of Science Education and Research Kolkata

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Indian Institute of Science Education and Research Mohali, Indian Institute of Science Education and Research Kolkata, Science and Engineering Research Board

OpenAlex ID: W7213270771

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