Year: 2026
Type: preprint
Abstract: ABSTRACT Availability of commercial antibodies for immunochemistry is typically limited to major model species. Researchers working on non-model organisms therefore often need either to generate novel species-specific antibodies or venture into expensive empirical screening from available antibody catalogues, hoping to find cross-reactive reagents. SixPack-AbScan is a free web server aiding researchers in transferring antibodies across species: using the available epitope-mapping information, the software performs a simple computational pre-screening of potential cross-reactivity. The workflow is species-agnostic and designed to help non-model-species researchers prioritize antibodies for experimental validation. A hit indicates sequence-level conservation of the epitopes and a high probability of cross-reactivity; the server does not model substitutions, structure, accessibility, expression or binding affinity. The web server is available at https://sixpack-abscan.serve.scilifelab.se . GRAPHICAL ABSTRACT
Author: Marco Grillo
Institutions: Stockholm University, Science for Life Laboratory
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7213279654