Work

From phenotypic screening to target and compound prioritization for autosomal dominant polycystic kidney disease

Year: 2026

Type: article

Abstract: AR-linked hypothesis and identified Esaxerenone as a compound-specific phenotypic hit; both require mechanistic confirmation and evaluation in additional disease models.

Source: SLAS DISCOVERY

DOI: 10.1016/j.slasd.2026.100338

Authors: David Alencar Araripe, Margarita Iljin, Hester Bange, Leo S. Price, Rongfang Liu, Daan van der Es, Laura H. Heitman, Dorien J.M. Peters, Gerard J.P. van Westen

Institutions: Leiden University, Leiden University Medical Center, Oncode Institute

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,070

Funders: Horizon 2020 Framework Programme, H2020 Marie Skłodowska-Curie Actions

Award: Drug repurposing and discovery multidisciplinary training network

OpenAlex ID: W7213315441

FWCI:

Cites: 68

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