Stress-induced Metabolic Remodeling of Adipose and Brain Tissue Revealed by Positron Emission Tomography
Year: 2026
Type: preprint
Abstract: Stress impacts our health and triggers physiological adaptations, yet the metabolic programs engaged during stress remain incompletely understood. To fill this knowledge gap, we utilize total-body positron emission tomography (PET), multi-OMICS, and endocrine profiling to assess how various murine stress models affect systemic metabolic remodeling. We find that acute immobilization and surgery activate brown adipose tissue as part of the stress response, independently of hypothermia, thereby acting as a highly stress-sensitive metabolic hub. Additionally, we identify stress-specific hypo- and hypermetabolic signatures in different brain regions, and distinguish networks between brain and adipose tissue depots across the different stress groups. Our work presents a novel perspective on stress and its mobilization of metabolic resources and identifies PET imaging of brain and adipose tissue as a valuable, minimally invasive technique for tracking metabolic stress responses in mice, with relevance for animal welfare and disease models, and translational impact for mental health studies and preventive medicine.
Authors: Maximilian Krisch, Öykü Özer, Jayne Louise Wilson, Sabine Macho-Maschler, Paul Ettel, Hanka Vrban, Alexander Grentner, Barbara Katharina Geist, Clara T.S. Mertel, Usevalad Ustsinau, Oana Kulterer, Joachim Friske, Thomas Wanek, Claudia Kuntner, Thomas Helbich, Stefan Grünert, Rupert Palme, Florian W. Kiefer, Thomas Weichhart, Cécile Philippe, Marcus Hacker, Chrysoula Vraka
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7213331190