Figure S4 from BRD9 Degraders Unleash GBAF Chromatin Remodeling Activity in Synovial Sarcoma
Year: 2026
Type: other
Abstract: Supplemental Figure S4 (associated with Figure 4). BRD9 degradation reduces PBAF and recovers CBAF in SyS. A. Glycerol gradients fractionated nuclear extracts, blotted for a variety of BAF component antibodies after DMSO control or WA-68 exposure for HS-SY-II cells. Green lines indicate the size fractions of GBAF complexes, cyan lines canonical BAF complexes, and purple line PBAF complexes. B. Glycerol gradients fractionated nuclear extracts, blotted for BAF component antibodies after JC2621 PDXs were treated with vehicle control saline or WA-68.
Authors: Jinxiu Li, Mary L. Nelson, Li Li, Xiaobo Xia, Christine Stephan, Katarzyna Modzelewska, Gary Yu, Iain Mulford, Honnappa Srinivas, Xinyi Ge, Sarah McCollum, Ewin R. Jones, Yixuan Guo, Xin Chen, Gregory Hollingworth, Thomas Zoller, Ensar Halilovic, Cedric R. Clapier, Aneasha F. Whittaker-Tademy, Tinya Abrams, Edmund Harrington, Sofia Gkountela, Giorgio G. Galli, Hans Voshol, Jason Thomas, Nathalie Carte, Xiaoyang Zhang, Katharine L. Diehl, David H. Lum, Martin Hirst, Jeffrey T. Yap, William Forrester, Bradley R. Cairns, Kevin B. Jones
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7213337767