Work

Scenario-based Robustness of Proton Arc Vs Impt for Prostate Sbrt Under Translational, Rotational, and Range Uncertainties

Year: 2026

Type: article

Abstract: Conclusions: This work proposes a reproducible methodology rather than a prescriptive standard.It provides a pragmatic framework for centers-particularly those early in proton therapy adoption-to derive local baselines from endpoint ratios, implement simple advisory levels, and incorporate a variable-RBE-aware QA step focused on detecting atypical plans.The method is not a toxicity predictor and does not claim that model-derived bio-dose represents true RBE.As a practical benefit, the isodose-interpretable bio-dose endpoints offer a conservative guardrail during IMPT adoption by helping maintain LET consistency and reducing implementation uncertainty.

Source: International Journal of Particle Therapy

DOI: 10.1016/j.ijpt.2026.101698