Work

A sulfinate–azide hybrid reagent for sequential radical fluoroalkylation and click reaction

Year: 2026

Type: article

Abstract: 2-Azido-1,1,2,2-tetrafluoroethanesulfinate is a new radical reagent to introduce the CF 2 CF 2 N 3 moiety to a variety of (hetero)aromatics, thiols and alkenes. The adducts were clicked to alkynes, including a modified antibody.

Source: Chemical Science

DOI: 10.1039/d6sc06249k

Authors: Pallavi Halkarni, Mykyta Ziabko, Veronika Vrábelová, Marek Opelka, Yu Qianfei, Xihe Bi, Sergeii Suikov, Petr Pospíšil, Tomáš David, Soňa Boháčová, Blanka Klepetářová, Petr Beier

Institutions: Czech Academy of Sciences, Charles University, Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Northeast Normal University, University of Pardubice

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Ústav organické chemie a biochemie Akademie věd České republiky

Award: G5093457562

OpenAlex ID: W7213363591

FWCI:

Cites: 44

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Related to: 10