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Distinct structural mechanisms drive gain-of-function activation of TMEM16E in gnathodiaphyseal dysplasia

Year: 2026
Type: preprint
DOI: 10.21203/rs.3.rs-10425456/v1
Authors: Alessio Accardi, Eleonora Di Zanni, Omar Alvarenga, Nicole Rychlik, Zhang Feng, Elizabeth Kim, George Khelashvili
Language: English
Open Access status: green
Funders: National Science Foundation, U.S. Department of Energy, Deutsche Forschungsgemeinschaft, National Institutes of Health, Office of Science, Weill Cornell Medical College, National Institute of General Medical Sciences
Awards: G121915436, G1567773112, G1645119126, Identification of potential drug binding sites within allosteric networks in cyclic nucleotide modulated channels, G203625172, G2411683797, G2584197162, G2988778103, G3097474150, G3739291073, G3945850812, G4036083762, G5357890501, G5619989149, G6128086324, G7734004253, G79964497, G8269158468, Graduate Research Fellowship Program (GRFP), G8906985441, G89955983
OpenAlex ID: W7213365536
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