Improving Guideline-Directed Medical Therapy in Hospitalized HFrEF Patients
Year: 2026
Type: article
Study design: Clinical Trial
Abstract: BACKGROUND: Guideline-directed medical therapy (GDMT) reduces mortality and rehospitalization in heart failure with reduced ejection fraction (HFrEF), yet many hospitalized patients are discharged without optimal therapy. PROJECT RATIONALE: A baseline audit at our community teaching hospital showed fewer than half of eligible patients were discharged on ≥3 GDMT pillars, driven by cost barriers, deferred titration, and inconsistent education. PROJECT SUMMARY: A multidisciplinary Plan-Do-Study-Act intervention standardized GDMT workflows, incorporating pharmacist-led admission review, structured checklists, teach-back counseling, a meds-to-beds program, and early outpatient follow-up. Among 62 postintervention versus 152 baseline patients, discharge on ≥3 pillars increased from 47.4% to 69.4% (P = 0.006), heart failure-specific 30-day readmissions decreased from 23.7% to 9.7% (P = 0.022), and all-cause readmissions from 30.9% to 16.1% (P = 0.028). LIMITATIONS: Modest postintervention sample size warrants cautious interpretation. TAKE-HOME MESSAGE: Structured, pharmacy-supported GDMT workflows improved prescribing performance and reduced 30-day readmissions in HFrEF.
Source: JACC Case Reports
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $850
OpenAlex ID: W7213428938