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Semi-synthesis of the C-terminal region of Pf RALP1: an alternative strategy for producing a hard-to-express merozoite protein

Year: 2026

Type: article

Abstract: Semi-synthetic Pf RALP1-C1, the C-terminal region of the indispensable Pf RALP1 protein, competitively blocks merozoite invasion of RBCs. This hard-to-express malaria antigen was produced via 3-segment native chemical ligation.

Source: RSC Chemical Biology

DOI: 10.1039/d6cb00176a

Authors: Akash Narayan, Sreejith Raran-Kurussi, Mrinal K. Bhattacharyya, Kalyaneswar Mandal

Institutions: Tata Institute of Fundamental Research, University of Hyderabad

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,962

Funders: Tata Institute of Fundamental Research, Department of Atomic Energy, Government of India

Award: G9000385091

OpenAlex ID: W7213440864

FWCI:

Cites: 62

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Related to: 10