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From Medication Appropriateness to Therapeutic Optimization: Why Multimorbidity Requires Explicit Reconciliation of Clinical Benefit, Treatment Burden, Feasibility, and Patient Priorities

Year: 2026

Type: article

Abstract: Medication appropriateness is an important component of medicines management, but multimorbidity creates therapeutic decisions in which a medication can be indication-concordant yet still be poorly aligned with the patient’s overall clinical situation. Disease-specific benefit, treatment burden, practical workability, and patient priorities may diverge, change over time, or operate at different levels of care. To develop an evidence-bounded conceptual model of therapeutic optimization that treat

Source: Annals of Pharmacy Practice and Pharmacotherapy

DOI: 10.51847/edbwn7dpbh

Authors: James Anderson, Maria Rossi, William Clark

Institutions: University of Manchester, University of Milan, The University of Melbourne

Topic: Pharmaceutical Practices and Patient Outcomes

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7213447249

FWCI:

Cites: 33

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