Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer
Year: 2025
Type: article
Study design: Observational Study
Abstract: Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta-analyzed >22 million variants for 398,238 women from the Ovarian Cancer Association Consortium (OCAC), UK Biobank (UKBB) and Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) to identify novel HGSOC susceptibility loci. Eight novel variants were associated with HGSOC risk. An interesting discovery biologically was TP53 3’-UTR SNP rs78378222-T’s association with HGSOC (per-T-allele relative risk (RR) = 1.44, 95% CI:1.28–1.62, P = 1.76 × 10−9). Polygenic scores (PGS) were developed using OCAC and CIMBA data and trained on FinnGen data. The optimal PGS included 64,518 variants and was associated with an odds ratio of 1.46 (95% CI:1.37–1.54) per standard deviation when validated in the UKBB. This study represents the largest HGSOC GWAS to date – demonstrating that improvements in imputation reference panels and increased sample sizes help to identify HGSOC associated variants that previously went undetected, ultimately improving PGS which can improve personalized HGSOC risk prediction.
Authors: Barnes, Daniel R, Tyrer, Jonathan P, Dennis, Joe, Leslie, Goska, Bolla, Manjeet K, Lush, Michael, Aeilts, Amber M, Aittomäki, Kristiina, Andrieu, Nadine, Andrulis, Irene L, Anton-Culver, Hoda, Arason, Adalgeir, Arun, Banu K, Balmaña, Judith, Bandera, Elisa V, Barkardottir, Rosa B, Berger, Lieke PV, Berrington de Gonzalez, Amy, Berthet, Pascaline, Białkowska, Katarzyna, Bjørge, Line, Blanco, Amie M, Blok, Marinus J, Bobolis, Kristie A, Bogdanova, Natalia V, Brenton, James D, Butz, Henriett, Buys, Saundra S, Caligo, Maria A, Campbell, Ian, Castillo, Carmen, Claes, Kathleen BM, Colonna, Sarah V, Cook, Linda S, Daly, Mary B, Dansonka-Mieszkowska, Agnieszka, de la Hoya, Miguel, deFazio, Anna, DePersia, Allison, Ding, Yuan Chun, Doherty, Jennifer A, Domchek, Susan M, Dörk, Thilo, Einbeigi, Zakaria, Engel, Christoph, Evans, D Gareth, Foretova, Lenka, Fortner, Renée T, Fostira, Florentia, Foti, Maria Cristina, Friedman, Eitan, Frone, Megan N, Ganz, Patricia A, Gentry-Maharaj, Aleksandra, Glendon, Gord, Godwin, Andrew K, González-Neira, Anna, Greene, Mark H, Gronwald, Jacek, Guerrieri-Gonzaga, Aliana, Hamann, Ute, Hansen, Thomas VO, Harris, Holly R, Hauke, Jan, Heitz, Florian, Hogervorst, Frans BL, Hooning, Maartje J, Hopper, John L, Huff, Chad D, Huntsman, David G, Imyanitov, Evgeny N, Izatt, Louise, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, John, Esther M, Kar, Siddhartha, Karlan, Beth Y, Kennedy, Catherine J, Kiemeney, Lambertus ALM, Konstantopoulou, Irene, Kupryjanczyk, Jolanta, Laitman, Yael, Lavie, Ofer, Lawrenson, Kate, Lester, Jenny, Lesueur, Fabienne, Lopez-Pleguezuelos, Carlos, Mai, Phuong L, Manoukian, Siranoush, May, Taymaa, McNeish, Iain A, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Mongiovi, Jennifer M, Montagna, Marco, Moysich, Kirsten B, Neuhausen, Susan L, Nielsen, Finn C
Institution: University of California, Irvine
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Defense, American Cancer Society, Susan G. Komen for the Cure, Breast Cancer Research Foundation, Oak Foundation, Ovarian Cancer Research Fund, Roswell Park Cancer Institute, Fisher Center for Alzheimer's Research Foundation, Minnesota Ovarian Cancer Alliance, State of Connecticut Department of Public Health, Beth Israel Deaconess Medical Center, Vanderbilt University, Oregon Health and Science University, University of Pennsylvania, Ohio State University, Mayo Foundation for Medical Education and Research, Memorial Sloan-Kettering Cancer Center, Vanderbilt-Ingram Cancer Center, University of Chicago, Univerzita Karlova v Praze, Lee Foundation, Rutgers Cancer Institute of New Jersey, Kansas Bioscience Authority, University of Pittsburgh, Fundación Mutua Madrileña, Georgetown University, McGill University, Dr. Ralph and Marian Falk Medical Research Trust, Faculty of Medicine, McGill University, Deutsches Krebsforschungszentrum, Kreftforeningen, Genome Canada, Moffitt Cancer Center, Cancer Research Society, Wellcome Trust, Ministère du Développement Économique, de l’Innovation et de l’Exportation, Ovarian Cancer Australia, Royal Marsden NHS Foundation Trust, Swedish Cancer Foundation, NorthShore University HealthSystem, Cedars-Sinai Medical Center, Génome Québec, Western Sydney Local Health District, Princeton Center for Complex Materials, Gray Foundation, Fondation du cancer du sein du Québec, Fred C. and Katherine B. Andersen Foundation, NRG Oncology, Amsterdam University Medical Centers, Lon V. Smith Foundation, Government of Canada, Cancer Research UK, National Institute for Health and Care Research, Department of Health and Social Care, University of Cambridge, University College London, European Commission, National Breast Cancer Foundation, Cancer Australia, Cancer Institute NSW, National Research Foundation, Cancer Association of South Africa, National Research Foundation Singapore, Deutsche Forschungsgemeinschaft, Institut National de la Santé et de la Recherche Médicale, Universiteit Leiden, Rijksuniversiteit Groningen, Fundação de Amparo à Pesquisa do Estado de São Paulo, Radboud Universiteit, Vrije Universiteit Amsterdam, Universiteit Maastricht, Bundesministerium für Bildung und Forschung, Terry Fox Foundation, Cancerfonden, Generalitat de Catalunya, Erasmus Medisch Centrum, Universität Wien, Ministero della Salute, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Ministerio de Economía y Competitividad, Ministry of Health, Labour and Welfare, Ministério da Ciência, Tecnologia e Inovação, Hungarian Scientific Research Fund, University of Toronto, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Korea Health Industry Development Institute, Israel Cancer Association, Fondation ARC pour la Recherche sur le Cancer, Ligue Contre le Cancer, Odense Universitetshospital, Peter MacCallum Cancer Centre, Helse Vest, Vetenskapsrådet, Lietuvos Mokslo Taryba, Maastricht Universitair Medisch Centrum, KWF Kankerbestrijding, Jewish General Hospital, NordForsk, Ministerio de Ciencia e Innovación, Associazione Italiana per la Ricerca sul Cancro, Academic Center for Education, Culture and Research, Leids Universitair Medisch Centrum, Norges Forskningsråd, Deutsche Krebshilfe, Radboud Universitair Medisch Centrum, Sigrid Juséliuksen Säätiö, Institut National Du Cancer, Clalit Health Services, Russian Science Foundation, Ministero dello Sviluppo Economico, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Pomorski Uniwersytet Medyczny W Szczecinie, Istituto Oncologico Veneto, Syöpäsäätiö, Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, Liga Portuguesa Contra o Cancro, Hebei Medical University, Centro de Investigación Biomédica en Red de Cáncer, Institut Català de la Salut, Freistaat Sachsen, BC Cancer Foundation, Hellenic Health Foundation, Kerry Group Kuok Foundation, Unicancer, Peter MacCallum Foundation, National Institutes of Health, Directorate for Biological Sciences, University of California, Los Angeles, University of Texas MD Anderson Cancer Center, Fox Chase Cancer Center, University of California, San Francisco, Cancer Center, University of Kansas, Health Canada, Canadian Institutes of Health Research, Medical Research Council, World Cancer Research Fund, National Health and Medical Research Council, Cancer Council Victoria, National Medical Research Council, Japan Society for the Promotion of Science, Instituto de Salud Carlos III, European Regional Development Fund, NIHR Cambridge Biomedical Research Centre, NIH Office of the Director, National Cancer Institute, National Institute of General Medical Sciences, National Center for Advancing Translational Sciences, Jonsson Comprehensive Cancer Center, European Social Fund, Medical Research and Materiel Command
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technologija krūties ir kiaušidžių vėžio predispoziciją turinčių pacienčių sveikam senėjimui, G3641918296, G364689131, G3652447071, G3668259588, G3671170512, G3675143906, G3676688267, G3679703240, G3683331093, G3686560373, G3696587015, G3697681713, G3699510083, G3708204173, G3710002767, Optimizando estrategias de secuenciación masiva para la identificación y traslación a la clínica de nuevos genes de susceptibilidad implicados en cáncer de mama familiar, G3713347624, G3713752515, G3714974232, G3718558835, G3723940138, G372475493, G3727700567, G3728986242, G3729156826, G3738001732, G3747421453, G375319704, G375538026, G3757718203, G3759739321, G3763983592, Elucidating Loci Involved in Prostate Cancer Suceptibility, G3774722636, G3775102187, G3775481441, HerediCaRe - Aufbau eines nationalen Registers zur Evaluierung und Verbesserung risiko-adaptierter Prävention für erblichen Brust- und Eierstockkrebs (Realisierungsphase), G3788767092, G3791138832, G3791714814, G3794511291, G3795131092, G3798981638, G3799250231, G3802047249, G380315410, G3804958746, G3807225764, G3808361620, G3816092139, Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention, G3827521508, G382879149, G3830541857, G3832074991, G3832503461, G3837471613, G3843026767, G3844753188, G3853559808, G3854560931, G3858419850, G3859539979, G3864189366, G3864320117, G3866391197, G387172998, G3875906436, G3878684983, G3885029063, G3891343362, G3894154293, G3895158111, G3897712702, G389926461, G3909662195, G3916914105, G3917360252, G3918072604, G3918807088, G3919846640, G3924142585, G3925546380, G3933833023, G3940010838, G3940514963, G394196338, G3947647216, G3948319897, G395896098, G3964026636, G3964357365, Dietary and Hormonal Determinants of Cancer in Women, G3968448507, G3970580488, G3974381433, G3978591521, G3979006103, G3980646122, G3981421899, G3990945386, G3993473912, G3994034673, G4010018867, G4012977212, G4015156572, G4017072919, G401803774, G4021080460, G4022758929, G4023530616, G4026108097, G4026196738, G4026445650, G4030124111, G4041385912, G4041890736, G4042319840, G4043398722, G404352023, G4044476773, G4049848471, G4049940523, G4051349196, G4052695615, G4061461591, G4065091416, G407478442, G4077774553, G4079302767, G4080027727, G4081633361, G4084983541, G4085715670, G4089375448, G4089957676, G4098640521, G4100649655, G4102770861, G4102827437, G4103474500, G4108058948, G410854802, G4108556986, G4111209380, G4113219329, G4114733266, G4119534169, G4119975330, G4121959493, G4126424415, G412838003, G4144805205, G414702837, G4148322860, G415230147, G4155712275, G4160964243, G4162991602, G4167275758, G4168635842, Desarrollo de estrategias terapéuticas personalizadas para los tumores malignos de las vainas de los nervios periféricos: modelos in vivo y farmacogenómica, G418074593, G4183505075, G4187108342, G4191254183, G4197410787, G4197772383, G4199372724, G4199943363, G4201696680, G4203948968, G4206490604, G4210055352, G4213141252, G4217511406, G4221275755, G4222884455, G422688925, G4232426906, G4233509591, G4234120248, G423622538, G424082930, G4249038968, G425152470, G4253600597, G4260388807, G4268494590, G4270344597, G4278807696, G428383045, G4284504048, G428660161, G429713427, G4299495634, G4300968980, G4303038735, G4305317257, G430627353, G431899019, NRG Oncology Network Group Operations Center, G4322304777, G4323113877, G4324473162, G4333708648, AOCS Clinical Follow-Up Core, G4339904293, G4345139362, G4346707325, G4349815490, G4350737453, G435179182, G4355771977, G4356861105, G4357685540, G4358476211, G4363360629, G4365090881, G4365922691, G4376790518, G4381062370, Australasian Biospecimen Network - Oncology, G4385717700, G4385785874, G4387780803, G4393399965, G439405029, G43956866, G4395741728, G440673340, G4407166175, G4409649582, G4409790911, G4409899835, G441052152, G4411541348, G4412180774, G44159516, G4430680974, G443470747, G443747538, G4449771222, G4458932437, G4462160033, G4470437464, G4473162978, G4475562558, G4478187868, G4488911226, G4494821125, G4499607632, G4499689463, G4500117056, G4500431135, G4505898643, G4508801274, G4516909651, G452089530, G4526522569, G4530141046, G4531705715, G4535106301, G4536765799, G4551976579, G4558954967, G4560117792, G4564174069, Health of vegetarians, G4572358134, G4572552886, G4573451601, G4574333488, G4575370609, G4594716893, G459595259, G4598064286, G4601496266, G4602816601, G4604761759, G4607708897, G4613208781, G4618848721, G463357850, G4634457378, G4634524342, G4638184864, G4639802573, G4655236649, G4662672464, G4666324002, G4671716571, G4675236536, G4678733857, G4682079261, G4686822778, G468703786, G4687915085, G4688365015, G4691118070, G4691630674, G4693376890, G4697235049, G4699008114, G4701026329, G4702869972, G4703448145, G4710177721, G4713990828, Risk and penetrance of mutations from breast cancer testing panels., G4721922943, G4722955430, G4730585134, G4739453685, G4739483508, G4740012054, G4753630297, G4758303473, G476489484, G4765274359, G4769362009, G4769469451, G4769804556, G4770718776, 漢代思想の研究-特に後漢末思想(王府,仲長統等)の研究, G4773629080, G4786373955, G4799095961, G4803287354, G4811780622, G4814591014, G4839762492, G48409658, G4849618962, G4856284552, G4857818444, G4859873005, G4873239205, G4879533352, G4885864782, G4887716027, G4892646750, G4893879946, G4902239870, G490534113, G4907478063, G4911194153, G4913827001, G4914661946, G4914835, G4915529853, G4920900562, G4923733781, G4934854569, Modelaje terapéutico del cáncer de mama triple-negativo, G494830712, G4950660695, G495186059, G4963598836, G4964662507, G496736080, G4977623329, G4977757174, G4979840178, G4980488893, G4983412712, G498433658, G4991056325, G4991908250, G4994324770, G499440518, G4996985803, G5002099500, G5004963360, G5007941840, G5009853252, G5015005981, G5018299172, G5019474394, G5025971311, G5029156483, G5035028408, G5035440390, G5035689153, G504460986, G5047213743, G5048543170, G505214610, G5052768465, G5056645209, G5058997197, G5059429344, G5061931730, G5063699180, G5065793941, G5068012532, G5068367211, G5069802979, G507168826, G5072279207, G5073708342, G507516432, G5082594465, G508357843, G508621415, G5098909591, G5102625768, G510737083, G5110970742, G5113021006, G5119219000, G5121539642, G5121713029, G5123028305, G5144603555, G5147415805, G5150118853, G5151594043, G5153584822, G5155055537, G5158692631, G5177168896, G5181373253, G5188380192, G5189646484, G5190555239, G5192555790, G5197845165, G5198239130, G5200234019, G5201694952, G5206190998, G5206874578, G520867115, G5209773453, G5216677969, G5218421771, G5218858701, G5221592869, G5222907127, G5224171919, G5229398360, G5233716593, G5235148864, G5235612687, G5236250921, G5258272776, G5259653062, G5260578936, G5268390784, G5272917877, G5273185502, G5277962741, G5281743283, G5282795702, G5294110089, G529633706, G5298817638, G5304242060, G5305488713, G5305809410, G5309266747, G5311311511, G5313425832, G5315697157, G531720922, G5321523552, G5321777280, G5328795535, G5330159664, Collaborative Genetic Study of Ovarian Cancer Risk, G53431648, G5343409947, G5344601884, G5344929899, G5351710239, G5356407723, G535691011, G5357465865, G535831174, G5366118659, G5370711850, G5373760811, G5374892841, G5375387566, G5375816427, G538122129, G5382674031, G5393094658, G5393642456, G5395379871, G5400679422, G5406065712, G5409203474, G5412032462, G5420429178, G5425491905, G5432244859, G5433877598, G5435070344, G5435148814, G543680480, G543783286, G5443321647, G5447392022, G5452161493, G5452432248, G5456958854, G5468790521, G5470642588, G547275475, G5473792555, G5475445602, G5482372644, G5486405922, G5491114930, G5496469482, G5500056455, G5509076196, G5513258459, G5519723108, G5520316217, G5520915018, G5524892003, G5525192448, G5527714048, G5529779505, CASE-CONTROL STUDY OF OVARIAN CANCER IN LOS ANGELES, G5537633645, G5547052656, G556326360, G5565827463, G5566577447, G556815181, G5568856568, G5568864849, G5578953934, G558017500, G5583696067, G5585565996, G5585590781, G5592112452, G5600012445, G5601597074, G5604875303, G5608258727, G5616697689, G5617688522, G5620470808, G5621875644, G5622398504, G5622672967, G563149733, G5635700996, G5637269007, G5643942056, G5645629167, G5646618515, G5649857278, G5651954792, G5654214539, G5656292200, G5659612911, G566671978, G5670176915, G5670860318, G5677030604, G5680710632, G5681652998, G5687020163, G5691624294, G569447510, G5694555675, Descubrimiento de nuevos genes y variantes genéticas en cáncer hereditario: estudios funcionales, de regulación del splicing y frecuencia poblacional de las variantes para su aplicaci, G569908600, G5699131004, G5702657623, G5706284561, G5706984478, G5714516760, G5719252827, G5719576428, G5731113435, G5736705792, G5738488509, G5742312296, G5750542632, G5750710683, G5750745757, G5752270261, G5756563332, G5757053897, G5758538982, G5763065391, G5768527752, G577119661, G5773300684, G577498864, G5783272435, G578395707, G5794032522, G5803083911, G5823312510, G5828200131, G5831092029, G5837662782, G5844522323, G5850682332, G5851393153, G586064783, G5868006920, G5868451842, G5869875709, G587200262, G5873433241, G5876566128, G5884150676, G5888609378, G588881265, G5894477417, G5897142711, G5899535470, G5901467367, G5902854375, G59107977, G5912378907, G5913770709, G5916996170, G5917683143, G5923636902, G5932435930, G5932924763, G5934054167, G5939395570, G5952534786, G5954635298, G5955236189, Detectie van lokaal uitgebreide en teruggekeerde endeldarmkanker met behulp van tumor-specifieke fluorescentie, G5965310296, G5965333527, G5987172331, G5990830295, G5992821780, G5994485482, G5994987104, G5997811978, G5999821407, G6000582506, G6002042860, G6007387519, G6012801195, G6013584675, G6014749904, G6020918748, G6021159705, G6022976577, G6025337639, G6028199577, G602992300, G6035964259, G6042031415, G6043120078, G6046728338, G6051881044, G6053637196, G60573655, G6059177416, G6062084349, G6066560486, G6069018159, G6074149125, G6075898064, G6078392164, G6091705888, G6099594453, G6100033090, G6100254670, G610220076, G6110847868, G6114257365, G6117244712, G6126144330, G6126609787, G6126614135, G6136237335, G613936551, G6142457952, G6144205333, G6161264265, G6175345339, G6177794165, G6178324646, G6179720485, G6182626225, G6185874248, G6187643630, G6191607766, G619603644, G6200764915, G6208198450, G6208597191, G6212483348, G621290712, G6217773214, G6223806083, G6228767644, G6229591247, G6238616637, G6242680863, G6242731818, G6245335255, G6247420843, G62519578, G6253228608, G6254892548, G6256309013, G6259367739, G6264211199, G6264272058, G6265702644, G6270943877, G6271087811, G6272687058, G6285063517, G6287947326, G6288781261, G6290490879, G6294906247, G6299407364, G6301433572, G6305665937, G6310760569, G6314523757, G6317768080, G6320156643, G6321812552, G6332630260, Community Cancer Genetics and Research Training (Revision), G634119927, G6342384842, G6343431347, G6343507173, G6346811214, G6349920531, G6352955597, G6366270716, G6367530758, G6370857267, G6371771718, G6372256998, G6393038893, G6394028603, G6394719143, G640002926, G6402529627, G640459779, G642200086, G6431979693, G6433449787, G6435968608, G6442500046, G6443441345, G6443445030, G6444761280, G6445710272, G6446665075, G6450786775, G6452362305, G6453734255, G6457389867, G6457924970, G6464926464, G6468308685, G64733685, G6473583094, G647474289, G6480339625, G6486574503, G6488024090, G6489462163, G6489958760, G6490068802, G6491230158, G6494632074, G650074167, G6505221676, G6505421423, G650596566, G6511332783, G6515215265, G6516220988, G652239100, G6524205025, G6532855740, G6536056355, G6536232728, G6549632455, G6552302344, G6554032491, G6558636245, G6559932184, G6560235290, G6566148188, G6570774229, G657255654, G6577598132, G6586556913, G6592368323, G6604307332, G6604594832, G6608264682, G6608891261, G6611506474, G6616185778, G6618381958, G6621232254, G6631454880, G6636911908, G6652302627, G6654466364, G6656156659, PLATYPUSES, G6663157969, G6667047877, G6671708962, G6675395858, G6680673728, G6681240295, G668614335, Epidemiology of Chronic Disease, Health Interventions and DNA Studies, G670051846, G6708517420, G6719391877, G6727411954, G673305001, G6741060998, G6744381054, G6753823748, G675740970, G6761260408, G6763731694, G6766485657, G6766894854, G6777778169, G6780254327, G6781708923, G6783010980, G6790994078, G6794387661, G6794500166, G6794567881, G6797955333, G6804027189, G6806151079, G6813853612, G6814299652, G6819482492, G6820515600, Análisis funcional de la reparación del ADN y expresión del ARN de genes clínicamente accionables de cáncer de mama/ovario hereditario en pacientes con un resultado no informativo tras un estudio de un pa, G6829211526, G6829762644, G6830391788, G6832116544, G6838654718, G6838805842, G6842736904, G6850563973, G6858204494, G6866210339, G6866558488, G6868151656, G6878602458, G6881479876, G6887972972, G6888779489, G6889597758, G6889763291, G6890531, G6895950328, G6898506723, G6902192277, G6914267691, G6920315723, G692825579, G6929791624, G6937116396, G6949614710, G6960682749, G6962756884, G6967976334, G6971553973, G6978069949, G6978709651, G6990177591, G6990806275, G699099564, G6999620226, G700021213, G7001586287, G7002991183, G7005327123, G7006486244, G7008669507, G7009610138, G7020115967, G7022277044, G7025202487, G7025781913, G7030639063, G7032774678, G7036369858, G7037647046, G7040807446, G7042089715, G704424639, G704544610, G7054766078, G7054985324, G7055847034, G7062678241, 内湾植物プランクトンの季節変化, 特に鞭毛藻類に関する研究, G7069699392, G707346186, G70736214, G7083853099, G7085323860, G709497006, G7095192201, G7096719997, G7107499398, G7115290980, G7116638684, G7116997479, G7124401860, G7129459928, G7133737134, G7140941202, G7151307261, G7151768789, G7152405674, G7165037524, G7175141390, G7180840450, G7181378667, G7183893864, G7187368266, G7192512427, G7199227476, G7199325825, G7206692317, G7208330911, Descifrando la complejidad genética del cáncer hereditario mediante un análisis multidimensional de un panel de genes de diseño propio, G7218065089, G7223051280, G7229355336, G7238546996, G7241566590, G7242219286, G7242493520, G7242785408, G7243203649, G7245015376, G7255232756, G7258059550, G7267409013, G7271584288, G7274315096, G7277877115, G7278023611, G7279312517, G7280168628, G7282210475, G7283889457, G7286015836, G7288270010, G7295776449, G7296172712, G7304657248, G7306252069, G7307876031, G7313467890, G7313779307, G731682097, G7321660720, G7326189359, G7328727475, G7337629570, G734060659, G734127494, G734892404, G7351505911, G7354982986, G7356264847, G7357522587, G7372524322, G7374748916, G7375233134, G7376122967, G737838840, G7383316951, G7390345804, G7393258936, G7400227903, G7400312528, G7402670107, G7402923325, G740425212, G7404474694, G740476103, G7406818343, G7408643460, G740865614, G7410254275, G7415157154, G7423961978, G7426181285, G7427462524, G7430234978, G7431072056, G7443999740, G7447125227, G7454601052, G7456659913, G7459520778, G7460484551, G7463418728, G7464850895, G7466598608, G7469845195, G7480002280, Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology, G7483307776, G7489957671, G749501992, G7501896692, G7502883741, G7503396464, G7505214508, G7505384502, G7510707455, G751474205, G7515492860, G751661945, G7531233806, G7533361206, G7533425060, G7545389969, G7548251299, G7550424651, G7551338843, G7556704279, G7558556141, G7569268906, G7570102734, G7570543806, G7570682278, G757122089, G7571934204, G7573107169, G7586037790, G7586968570, G7596519453, G7597388277, G7600088736, G7601185679, G7603046857, G7603965662, G7604953284, G7608403635, G7618966743, G7622658541, G7624991799, G7625083360, G762983994, G7635722955, G764070827, G7646326732, G765003839, G7652198732, G7652759735, G7652900232, G7659260347, G7660541068, G7663583697, G7666496759, G7668211347, G7672802699, G7673088783, G7675036220, G7680442207, G7680822247, G7684595986, G7689122240, G7691366920, G7692014440, G7697784111, G7700294005, G7701156946, G7701893839, G7704992235, G7711856627, G7714640921, G7720439865, G7720878368, G7724311201, G7724952580, G7725754312, G7730201318, G7736467179, G7741185395, G7743229171, G7755870183, G7756110719, G7769187891, G777410012, G7779195321, G7779672165, G7780309776, G7780900452, G778261475, G7787200052, G7792675715, G7796364618, G7797354937, G7801223132, G7805419838, G7806279721, G7808646444, G7811242667, G7813998140, G78141878, G7823126468, G782458776, G7825718492, G7827517260, G782985501, G7829886713, G7832053670, G7835278444, G7838322234, G7847239149, G7850585328, G7853538257, G78608705, G7870391627, G7875552478, G7875995065, G7877306337, G7882455590, G7885991059, G7888071330, G7891086452, G7891939106, Identifying and validating novel susceptibility genes for breast cancer, G790382466, G7912380902, G7912609137, G7923577054, G7926178030, G7931532932, G7935657002, G7936870691, G7938441476, G7939399614, G7941428382, G7943694199, G7959980841, G7960446114, G7973277461, G7975960458, G7978929429, G7979222046, G7982317279, G7983219509, G7983476435, G7984748549, G7989503144, G7989612811, G7992389077, G7993655663, G7997325378, G7998126057, G8000121040, G8001103002, G8012318887, G801495889, G8019403889, G80232628, G8028536217, G8028941638, G8030239839, G8037172431, G8041053323, G8045650276, G8047114668, G8050896463, G8055976186, G8057958628, G8062165187, G8064793800, G8066292779, G8067913783, Australian Ovarian Cancer Study (AOCS), G808787520, G8092145710, G810297196, G8121012253, G8123307142, G8123808567, G8124260371, G8133016523, G8135003176, G8135679676, G8147327976, G8155739244, G8162341385, G8168835903, G817199534, G817390530, G8184178841, G8189971061, G8190265398, G8197361807, G8200819307, G8205431335, G8209208257, G821701785, G8217976212, G8225165655, G8266408936, G826662582, G8266707362, G8271451488, G827758369, G8278688803, G827920996, G8279237360, G8286131369, G8296414749, G8296958090, G829717837, G829786726, G8303603054, G8304451412, G8307564395, G8313202159, G8319896143, G8320489521, G8331243404, G8331670928, G8333297635, G8334085739, G8339003697, G8340269215, G8344269847, G8344375360, G8347284120, G835355920, G836092046, Mitochondrial DNA and Ovarian Cancer Risk and Survival, G8374761964, G8380748540, G8386849510, G8389879771, G8394571607, G8399575726, G840112335, Targeting the allosteric control of alarmone synthetases to tackle bacteria persistence, G8402321647, G8403132807, G8405173764, G8407261631, Collaborative Oncological Gene-environment Study, G8411222527, G8411541462, G8413675353, G8427092016, G842774673, G8429796442, G8429832770, G8434894996, G8435125888, G8437818926, G8440613414, G844520391, G8450775414, G8451314362, G8451975646, G845286615, G8453733030, G8454392890, G846045368, G8461568454, G8478581475, G8480575570, G848064092, G8481498028, G848467821, G848473175, G8491322400, G8492020821, G8495212504, G8496182200, G8498102853, G8502094352, G8503305451, G8505307412, G8508326818, G8512272119, G8514611816, G8525262851, G8525613357, G8526228613, G8526292878, G8528971028, G8536695271, G8537673830, G8537738258, G8538137338, G8538983969, G8539341629, G8542687542, G8543079533, G8548670447, G8548705263, G8558472123, G856684225, G8570027088, G8575958574, Risk and prognostic factors for breast cancer of different immunohistochemical subtypes, G8576833329, G8578517998, G8578973111, G858604948, G8594339963, G8604866701, G8605664644, G8611704976, G8614998164, G8625776885, G862694305, G8630982842, G8640972091, G864128669, G8651849717, G8652312193, G8652899496, G8656021485, G8656305928, G8658451913, G8658736651, G8668082143, G8671336844, G8674255670, G8680260576, G8691862652, G8694687378, G8702800630, G8703060161, G8704580372, G8705823880, G871183627, G8716707177, G8716998914, G8717574252, G8718893896, G872381313, G8725735482, G8727185569, G8728968579, G8731644897, G8765552554, G8767531680, G876765158, G8770881172, G8775732090, G8776055046, G8776062500, G8781522573, G878788715, G8793360539, G8801411434, G880611044, G8807041785, G8811756736, G8812071599, G88130622, G8813442493, G8814178712, G8814553523, G8817123950, G8818365897, G8820065740, G8820111440, 魚類の病理組織に関する研究, G883206123, G8834430567, G8846336397, G8852162205, G8853217771, G8854317076, G885693336, G8864782299, G8867963557, G8868216078, G8869854444, G887255577, G8880508232, PRACTICAL Australia, G8892260180, G8900174105, G8901774384, G8908128081, G8910843809, G8918134885, G8919560729, G8920032475, G892034620, G892350892, G8924490982, G8925382016, G895030187, G8953328912, G895493773, G8956949479, G8959392569, G8959936493, G8960002408, G8964342090, G8973559178, G8974852769, G897858774, G8978728421, G8985544784, The genetics of weight, BMI, adiposity and obesity, G8993121883, G8999001090, G9000001642, G9000003249, G9000004104, G9000004656, G9000007198, G9000007830, G9000016153, G9000017222, G9000018137, G9000019617, G9000020071, G9000022926, G9000025899, G9000028669, G9000028950, G9000031556, G9000031659, G9000033067, G9000038231, G9000039166, G9000039344, G9000040826, G9000047811, G9000048109, G9000052278, G9000053679, G9000055130, G9000055689, G9000056976, G9000058679, G9000073185, G9000073510, G9000074379, G9000076967, G9000077506, G9000083910, G9000084571, G9000092332, G9000099730, G9000101281, G9000106153, G9000108862, G9000111071, G9000118703, G9000119294, G9000123264, G9000124663, G9000126810, G9000127251, G9000138654, G9000142182, G9000142273, G9000143408, G9000148858, G9000150817, G9000152200, G9000152323, G9000155148, G9000157792, G9000159563, G9000160301, G9000163464, G9000164272, G9000175716, G9000185549, G9000190097, G9000192259, G9000194311, G9000194421, G9000200580, G9000204832, G9000216949, G9000219434, G9000226715, G9000230084, G9000248580, G9000272137, G9000273410, G9000273748, G9000275884, G9000282203, G9000286278, G9000301350, G9000313436, G9000317346, Cancer Center Support Grant, Georgetown University Lombardi Comprehensive Cancer Center Support Grant, Cancer Center Support Grant, Mayo Clinic Comprehensive Cancer Center Support Grant, Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk, Moffitt Cancer Center Support Grant, The Kansas Institute for Precision Medicine, Resolving the cancer relevance of predisposition gene mutations, University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG), G901453306, G921190430, G924880562, G931469340, G93590137, G93940065, G942468893, G952755447, G958755025, G966753049, G969847122, G975188494, G980830052, G988107449
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