Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials
Year: 2026
Type: article
Abstract: BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaboration ICH data set. METHODS: This was an observational analysis of pooled individual participant data from 16 completed randomized controlled trials of blood pressure-lowering treatment in acute ICH, based on the Blood pressure in Acute Stroke Collaboration data set. Generalized linear mixed models with inverse probability of treatment weighting (IPTW) were used to determine the association between regions (Asia [primarily East and South Asia] versus non-Asia) and clinical outcomes including neurological deterioration within 7 days, hematoma expansion at 24 hours (absolute ≥6 mL or relative ≥33%), and death or dependency (modified Rankin Scale scores, 3–6), major disability(modified Rankin Scale score, 3–5), death alone at 90 days. RESULTS: Among 6221 patients (age, 63.3±13.0 years; female 36.4%), 3494 (56.2%) were from Asia. ICH participants from Asia had a significantly reduced risk of death or dependency (unadjusted odds ratio [OR], 0.44 [95% CI, 0.39–0.51]; IPTW-weighted OR, 0.67 [95% CI, 0.58–0.77]); and major disability (unadjusted OR, 0.49 [95% CI, 0.42–0.56]; IPTW-weighted OR, 0.67 [95% CI, 0.57–0.78]) at 90 days, neurological deterioration (unadjusted OR, 0.63 [95% CI, 0.52–0.77]; IPTW-weighted OR, 0.70 [95% CI, 0.56–0.89]) within 7 days, in comparison to those from non-Asia regions. However, there were no differences for hematoma expansion ( P =0.97) at 24 hours or death ( P =0.23) at 90 days using IPTW. Additionally, there were no significant interactions between blood pressure–lowering treatment and region (Asia versus non-Asia) for either outcome using IPTW. CONCLUSIONS: Participants from East and South Asia had a favorable functional recovery and a lower risk of neurological deterioration compared with those from non-Asian regions after adjustment for confounders, with no differences in hematoma expansion at 24 hours after ICH. These findings suggest that future ICH studies on clinical outcomes should consider regional differences.
Source: Stroke
Authors: Shoujiang You, Menglu Ouyang, Tom J. Moullaali, Else Charlotte Sandset, Lisa J. Woodhouse, Qiang Li, Lili Song, Zhe Kang Law, Xinwen Ren, Qiao Han, Chen Chen, Hisatomi Arima, Ken Butcher, Candice Delcourt, Yongjun Cao, Kailash Krishnan, Leon Edwards, Salil Gupta, Wen Jiang, Sebastian Koch, John Potter, Adnan I. Qureshi, Thompson G. Robinson, Rustam Al-Shahi Salman, Jeffrey L. Saver, Nikola Sprigg, Joanna Wardlaw, Craig S. Anderson, Philip M. Bath, John Chalmers, Xia Wang, Yuko Palesch, Nerses Sanossian, Eivind Berge, Janneke Horn
Institutions: Soochow University, Second Affiliated Hospital of Soochow University, The George Institute for Global Health, Oslo University Hospital, Stiftelsen Norsk Luftambulanse, Shanghai Center for Brain Science and Brain-Inspired Technology, Nottingham University Hospitals NHS Trust, Shanghai East Hospital, Fukuoka University, Prince of Wales Hospital, Macquarie University, Royal Prince Alfred Hospital, Army Hospital Research and Referral, Xijing Hospital, Air Force Medical University, University of Miami, University of East Anglia, Norfolk and Norwich University Hospital, University of Missouri, NIHR Leicester Biomedical Research Centre, University of California, Los Angeles
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7213488348
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