Global Postural Reeducation in Mild Alzheimer’s Disease: A Secondary Analysis of an RCT
Year: 2026
Type: article
Abstract: BackgroundDepression and neuropsychiatric symptoms are common in Alzheimer's disease (AD) and may contribute to functional decline and reduced quality of life.MethodsThis secondary analysis used data from a randomized controlled trial (NCT03732053). Fifty-eight participants were analyzed: 36 received supervised GPR twice weekly for 24 weeks and 22 received usual care. Outcomes included the Geriatric Depression Scale (GDS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Barthel Index, and Performance-Oriented Mobility Assessment (POMA). Repeated-measures ANOVA and baseline-adjusted analyses were performed.ResultsAt 24 weeks, GDS scores were lower with GPR than usual care (4.72 ± 2.36 vs. 8.41 ± 2.15; p < 0.001). Significant group × time effects were observed for NPI, MMSE, Barthel Index, and POMA (all p < 0.001).ConclusionGPR may provide complementary benefits across psychological, cognitive, and functional outcomes in mild AD, although baseline imbalance and differential attrition warrant cautious interpretation.
Authors: Orges Lena, Jasemin Todri
Institution: Universidad Católica de Murcia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,650
OpenAlex ID: W7213535097