Work

Isatin derivatives as potent cholinesterase inhibitors: recent developments and future challenges

Year: 2026

Type: review

Abstract: -substitution, and molecular hybridization on inhibitory potency and selectivity. This review summarizes the most promising isatin-based cholinesterase inhibitors reported from 2020 to the present, highlighting their biological activities, structure-activity relationships, and potential for the development of next-generation anti-Alzheimer therapeutics.

Source: RSC Advances

DOI: 10.1039/d6ra06493k

Authors: Muhammad Shahzad, Alia Mushtaq, Christophe Rochais, Muhammad Moazzam Naseer

Institutions: Quaid-i-Azam University, Normandie Université, Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen Normandie

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042